Reporting centers and number of transplants performed
 (Dec 31, 2019)
COUNTRY CITY HOSPITAL No of TX No of TX/Country
Portugal Lisbon Hospital Curry Cabral 273 591
Porto Hospital Sto Antonio 236
Coimbra Coimbra University Hospital 82
France Villejuif Hospital Paul Brousse/Kremlin Bicêtre 181 195
Lyon Hospital Edouard Herriot 5
Strasbourg Hôpital Hautepierre 4
Clichy Hospital Beaujon 3
Marseille Hospital de la Conception 2
Sweden Stockholm Karolinska University Hospital Huddinge 66 83
Gothenburg Sahlgrenska University Hospital 16
  Uppsala Uppsala University Hospital 1  
USA Rochester Mayo Clinic 38 82 
Burlington Lahey Clinic Medical Center 12
San Francisco UCSF Medical Center 10
Miami University of Miami 6
Philadelphia The Penn Transplant Center 5
Phoenix Mayo Clinic 4
Baltimore University of Maryland 3
Chapel Hill UNC Comprehensive Transplant Center 2
Pittsburgh Thomas E Starzl Transplantation Institute 1
Cleveland University Hospitals of Cleveland 1
Spain Barcelona Hospital de Bellvitge 43
 68
Seville University Hospital Virgen del Rocio 15
Vizcaya Hospital de Cruces Barakaldo 6
  Barcelona Hospital Vall D'Hebron 2
   Pamplona  Clínica Universitaria  2
Germany Mainz Der Johannes Gutenberg Universität 24 59
Hannover Medizinische Hochschule 15
Heidelberg Chirurgische Universitätsklinik 10
Tübingen Klinikum der Universität  10 
Münster Universitätsklinikum 1
Brazil São Paulo Hospital Albert Einstein 36 57
  Santo Amaro Oswaldo Cruz University Hospital 12  
  Rio de Janeiro Federal University of Rio de Janeiro 9  
         
Japan Kumamoto Kumamoto University Hospital 25 54
  Kyoto Kyoto University 10  
Matsumoto Shinshu University Hospital 7
Tokyo National Center for Child Health and Development 4
Tokyo Tokyo University Hospital 3
Niigata Niigata University Hospital 2
Sapporo Sapporo University Hospital 2
Fukuoka Kyushu University 1
Belgium Brussels UCL St Luc 14 21
Liège CHU Sart Tilman 4
Gent University Hospital 3
China Beijing Beijing Friendship Hospital 17 18
  Hong Kong Queen Mary Hospital 1  
Switzerland Genève Hospital Cantonal 10 15
Bern Inselspital 5
UK London King´s College 11 12
Birmingham Queen Elizabeth Hospital 1
Canada London London Health Science Center 4 9
Toronto Toronto General Hospital 3
Montreal Hospital Saint-Luc 2
Netherlands Groningen University Hospital 5 7
Rotterdam University Medical Center 2
Italy Torino Molinette Hospital 5 7
  Milan National Cancer Institute 1  
Milan Hospital Maggiore 1
India New Delhi Sir Ganga Ram Hospital 1 3
  Haryana Medanta - The Medicity 1  
  Coimbatore Kovai Medical Center and Hospital 1  
         
Australia Sydney Royal Prince Alfred Hospital 2 2
Taiwan Taipei Taipei Veterans General Hospital 2 2
Argentina Buenos Aires Hospital C Argerich 1 1
Romania Bucharest Fundeni Clinical Institute 1 1
Norway Oslo Rikshospitalet 1 1

Recipient characteristics:

Sex distribution: Male 74% / Female 26%

Age: Mean 55.5±10.6 yrs, median 57.1 yrs, range 0.3 – 73.9  

Indications for domino liver transplantation No of cases

Primary hepatic malignancy 

540
Metastatic hepatic malignancy          30 
Alcoholic cirrhosis 239
Cirrhosis secondary to hepatitis B and C 216
Retransplantation 67
Other miscellaneous diagnoses 184
Diagnosis not specified 13

Donor diseases:

FAP, Fibrinogen a-chain amyloidosis, Hyperoxalosis , Maple Syrup Urine Disease, Hypercholesterolemia, Hemochromatosis, Wilson disease, Hyperhomocysteinemia, Ornithine Transcarbamylase Deficiency, Methylmalonic aciduria, Citrullinemia, Crigler Najjar, Methionemia, Propionic acidemia

 

Main causes of death (only recipients of FAP livers):

Tumor recurrence 21%

Septicemia 15%

Cardiac related deaths 7%

Peroperative deaths 4%

 

Conclusion:

Domino liver transplantation demonstrate excellent results and is a valuable donor liver resource to selected patients. However, the risk of disease transmission in a proportion of patients is real and needs to be considered.