Reporting centers and number of transplants performed
|
||||
| COUNTRY | CITY | HOSPITAL | No of TX | No of TX/Country |
| Portugal | Lisbon | Hospital Curry Cabral | 273 | 591 |
| Porto | Hospital Sto Antonio | 236 | ||
| Coimbra | Coimbra University Hospital | 82 | ||
| France | Villejuif | Hospital Paul Brousse/Kremlin Bicêtre | 181 | 195 |
| Lyon | Hospital Edouard Herriot | 5 | ||
| Strasbourg | Hôpital Hautepierre | 4 | ||
| Clichy | Hospital Beaujon | 3 | ||
| Marseille | Hospital de la Conception | 2 | ||
| Sweden | Stockholm | Karolinska University Hospital Huddinge | 66 | 83 |
| Gothenburg | Sahlgrenska University Hospital | 16 | ||
| Uppsala | Uppsala University Hospital | 1 | ||
| USA | Rochester | Mayo Clinic | 38 | 82 |
| Burlington | Lahey Clinic Medical Center | 12 | ||
| San Francisco | UCSF Medical Center | 10 | ||
| Miami | University of Miami | 6 | ||
| Philadelphia | The Penn Transplant Center | 5 | ||
| Phoenix | Mayo Clinic | 4 | ||
| Baltimore | University of Maryland | 3 | ||
| Chapel Hill | UNC Comprehensive Transplant Center | 2 | ||
| Pittsburgh | Thomas E Starzl Transplantation Institute | 1 | ||
| Cleveland | University Hospitals of Cleveland | 1 | ||
| Spain | Barcelona | Hospital de Bellvitge | 43 |
68 |
| Seville | University Hospital Virgen del Rocio | 15 | ||
| Vizcaya | Hospital de Cruces Barakaldo | 6 | ||
| Barcelona | Hospital Vall D'Hebron | 2 | ||
| Pamplona | Clínica Universitaria | 2 | ||
| Germany | Mainz | Der Johannes Gutenberg Universität | 24 | 60 |
| Hannover | Medizinische Hochschule | 15 | ||
| Heidelberg | Chirurgische Universitätsklinik | 10 | ||
| Tübingen | Klinikum der Universität | 10 | ||
| Münster | Universitätsklinikum | 1 | ||
| Brazil | São Paulo | Hospital Albert Einstein | 36 | 57 |
| Santo Amaro | Oswaldo Cruz University Hospital | 12 | ||
| Rio de Janeiro | Federal University of Rio de Janeiro | 9 | ||
| Japan | Kumamoto | Kumamoto University Hospital | 25 | 54 |
| Kyoto | Kyoto University | 10 | ||
| Matsumoto | Shinshu University Hospital | 7 | ||
| Tokyo | National Center for Child Health and Development | 4 | ||
| Tokyo | Tokyo University Hospital | 3 | ||
| Niigata | Niigata University Hospital | 2 | ||
| Sapporo | Sapporo University Hospital | 2 | ||
| Fukuoka | Kyushu University | 1 | ||
| Belgium | Brussels | UCL St Luc | 14 | 21 |
| Liège | CHU Sart Tilman | 4 | ||
| Gent | University Hospital | 3 | ||
| China | Beijing | Beijing Friendship Hospital | 17 | 18 |
| Hong Kong | Queen Mary Hospital | 1 | ||
| Switzerland | Genève | Hospital Cantonal | 10 | 15 |
| Bern | Inselspital | 5 | ||
| UK | London | King´s College | 11 | 12 |
| Birmingham | Queen Elizabeth Hospital | 1 | ||
| Canada | London | London Health Science Center | 4 | 9 |
| Toronto | Toronto General Hospital | 3 | ||
| Montreal | Hospital Saint-Luc | 2 | ||
| Netherlands | Groningen | University Hospital | 5 | 7 |
| Rotterdam | University Medical Center | 2 | ||
| Italy | Torino | Molinette Hospital | 5 | 7 |
| Milan | National Cancer Institute | 1 | ||
| Milan | Hospital Maggiore | 1 | ||
| India | New Delhi | Sir Ganga Ram Hospital | 1 | 3 |
| Haryana | Medanta - The Medicity | 1 | ||
| Coimbatore | Kovai Medical Center and Hospital | 1 | ||
| Australia | Sydney | Royal Prince Alfred Hospital | 2 | 2 |
| Taiwan | Taipei | Taipei Veterans General Hospital | 2 | 2 |
| Argentina | Buenos Aires | Hospital C Argerich | 1 | 1 |
| Romania | Bucharest | Fundeni Clinical Institute | 1 | 1 |
| Norway | Oslo | Rikshospitalet | 1 | 1 |
| New Zealand | Auckland | Auckland City Hospital | 1 | 1 |
Recipient
characteristics:
Sex
distribution: Male 74% / Female 26%
Age:
Mean 55.5±10.6 yrs, median 57.1 yrs, range 0.3 – 73.9
| Indications for domino liver transplantation | No of cases |
|
Primary hepatic malignancy |
539 |
| Metastatic hepatic malignancy | 30 |
| Alcoholic cirrhosis | 239 |
| Cirrhosis secondary to hepatitis B and C | 216 |
| Retransplantation | 67 |
| Other miscellaneous diagnoses | 186 |
| Diagnosis not specified | 13 |
Donor risk (only FAP donors):
One year survival in FAP patients who were donors compared to non-donors were not significantly different, indicating no imposed risk to donate
| Donor diseases other than FAP | No of donors |
|
Maple Syrup Urine Disease |
16 |
| Fibrinogen a-chain amyloidosis | 6 |
| Hyperoxalosis | 4 |
| Hypercholesterolemia | 4 |
| Ornithine Transcarbamylase Deficiency | 2 |
| Hemochromatosis | 2 |
| Wilson disease | 1 |
| Hyperhomocysteinemia | 1 |
| Methylmalonic aciduria | 1 |
| Citrullinemia | 1 |
| Crigler Najjar | 1 |
| Methionemia | 1 |
| Propionic acidemia | 1 |
| Main causes of death (only recipients of FAP livers | % of diseased patients |
|
Peri-operative deaths |
4% |
| Tumor recurrence | 20% |
| Septicemia | 13% |
| Cardiac related deaths | 7% |
| Liver-related deaths | 7% |
| Recurrence of original disease (non-tumoral) | 5% |
| De novo tumor | 5% |
| Multi organ failure | 5% |
| Other | 19% |
| Not reported | 15% |
Domino
liver transplantation offers excellent outcomes for selected recipients and expands the donor pool.
Yet, the risk of disease transmission requires careful consideration.
FAP patients show no elevated risk when serving as domino donors.